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Can B-cell tolerance be induced by oligovalent thymus dependent antigens?

Abstract:

Spleen cells from adult mice were rendered "tolerant" to TNP by exposing cells in vitro to large concentrations of TNP10BSA. After such treatment the residual response to TNP was measured using TNP-LPS as antigen in vitro or in vivo. The "tolerance" observed in this system was not reversed by treating the cells with trypsin, nor by using non-specific polyclonal activators. Furthermore, responsiveness to TNP-LPS in vitro was not substantially restored when such "tolerant" cells were "parked" i...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Immunology More from this journal
Volume:
32
Issue:
5
Pages:
657-667
Publication date:
1977-05-01
EISSN:
1365-2567
ISSN:
0019-2805
Language:
English
Keywords:
Pubs id:
pubs:16281
UUID:
uuid:8f9ea447-ca4f-4cbc-8230-03ec60e73a95
Local pid:
pubs:16281
Source identifiers:
16281
Deposit date:
2012-12-19

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