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NY-ESO-1 protein glycosylated by yeast induces enhanced immune responses.

Abstract:

Vaccine strategies that target dendritic cells to elicit potent cellular immunity are the subject of intense research. Here we report that the genetically engineered yeast Saccharomyces cerevisiae, expressing the full-length tumour-associated antigen NY-ESO-1, is a versatile host for protein production. Exposing dendritic cells (DCs) to soluble NY-ESO-1 protein linked to the yeast a-agglutinin 2 protein (Aga2p) protein resulted in protein uptake, processing and MHC class I cross-presentation ...

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Publication status:
Published

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Publisher copy:
10.1002/yea.1796

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Journal:
Yeast (Chichester, England)
Volume:
27
Issue:
11
Pages:
919-931
Publication date:
2010-11-05
DOI:
EISSN:
1097-0061
ISSN:
0749-503X
URN:
uuid:8f94e3a1-2817-4f50-984d-6182d0adf0e3
Source identifiers:
96044
Local pid:
pubs:96044

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