Thesis
Investigating the role of DNA double strand break repair in determining sensitivity to radiotherapy fraction size
- Abstract:
-
The dose of curative radiotherapy (RT) for cancer is commonly limited by adverse effects presenting years later. Late reacting normal tissues are, on average, more sensitive to the size of daily doses (fractions) than early reacting normal tissues and cancers. Clinical trials have shown breast cancers to be one exception to this rule, in that they are as sensitive to fraction size as the late reacting normal tissues. This has led to the adoption of hypofractionation (use of fractions >2...
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Authors
Contributors
+ Helleday, T
- Division:
- MSD
- Department:
- Oncology
- Sub department:
- CRUK/MRC Ox Inst for Radiation Oncology
- Role:
- Supervisor
+ Yarnold, J
- Division:
- MSD
- Department:
- Oncology
- Sub department:
- CRUK/MRC Ox Inst for Radiation Oncology
- Role:
- Supervisor
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:8f941f8c-fa0d-4936-aac9-11549aaecb94
- Local pid:
-
ora:8205
- Deposit date:
-
2014-03-14
Terms of use
- Copyright holder:
- Dr Navita Somaiah
- Copyright date:
- 2014
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