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Journal article

Selection of complementary single-variable domains for building monoclonal antibodies to native proteins.

Abstract:

Antibodies are now indispensable tools for all areas of cell biology and biotechnology as well as for diagnosis and therapy. Antigen-specific single immunoglobulin variable domains that bind to native antigens can be isolated and manipulated using yeast intracellular antibody capture technology but converting these to whole monoclonal antibody requires that complementary variable domains (VH or VL) bind to the same antigenic site. We describe a simple approach (CatcherAb) for specific isolati...

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Publisher copy:
10.1093/nar/gkp069
Journal:
Nucleic acids research More from this journal
Volume:
37
Issue:
5
Pages:
e41
Publication date:
2009-04-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:324314
UUID:
uuid:8f830ab0-9e2b-4bad-9518-4394044e8847
Local pid:
pubs:324314
Source identifiers:
324314
Deposit date:
2013-11-16

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