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Phosphorylation-dependent migration of retinoblastoma protein into the nucleolus triggered by binding to nucleophosmin/B23.

Abstract:

Underphosphorylated retinoblastoma (Rb) protein inhibits progression around the cell cycle by binding to transcription factors like E2F; subsequent hyperphosphorylation of Rb protein releases E2F from the complex so that it can then drive the cell into S phase. We immunolocalized Rb protein in human cells during the cell cycle. Rb protein translocated into nucleoli after DNA replication completed, and the nucleolar Rb was shown to be in the hyperphosphorylated form by immunoblotting. This for...

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Publication status:
Published

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Publisher copy:
10.1006/excr.2002.5523

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Journal:
Experimental cell research More from this journal
Volume:
276
Issue:
2
Pages:
233-241
Publication date:
2002-06-01
DOI:
EISSN:
1090-2422
ISSN:
0014-4827

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