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The causal roles of vitamin B12 and transcobalamin in prostate cancer: can Mendelian randomization analysis provide definitive answers?

Abstract:

Circulating vitamin B12 (cobalamin/B12) and total transcobalamin (tTC) have been associated with increased and reduced risk, respectively, of prostate cancer. Mendelian randomization has the potential to determine whether these are causal associations. We estimated associations of single nucleotide polymorphisms in B12-related genes (MTR, MTRR, FUT2, TCN2, TCN1, CUBN, and MUT) with plasma concentrations of B12, tTC, holo-transcobalamin, holo-haptocorrin, folate, and homocysteine and with pros...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Authors


Collin, SM More by this author
Metcalfe, C More by this author
Palmer, TM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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G0600705/Medical Research Council More from this funder
NF-SI-0509-10242/Department of Health More from this funder
G0900871/Medical Research Council More from this funder
G0601625/Medical Research Council More from this funder
Publisher:
e-Century Publishing Publisher's website
Journal:
International Journal of Molecular Epidemiology and Genetics, IJMEG Journal website
Volume:
02
Issue:
04
Pages:
316-327
Publication date:
2011-12-15
Acceptance date:
2011-08-23
EISSN:
1948-1756
Pubs id:
pubs:222339
URN:
uri:8f4a689b-0c86-4229-ac2e-00e28dfab693
UUID:
uuid:8f4a689b-0c86-4229-ac2e-00e28dfab693
Local pid:
pubs:222339

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