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When should a new test become the current reference standard?

Abstract:

The evaluation of claims that a new diagnostic test is better than the current gold standard test is hindered by the lack of a perfect reference judge. However, this problem may be sidestepped by focusing on the clinical consequences of the decision rather than on estimation of accuracy. Consequences can be assessed by use of a "fair umpire" test that is not perfect yet can discriminate between disease and nondisease cases and is not biased in favor of 1 test. This article discusses 3 princip...

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-CTU
Journal:
Annals of internal medicine
Volume:
149
Issue:
11
Pages:
816-822
Publication date:
2008-12-05
DOI:
EISSN:
1539-3704
ISSN:
0003-4819
URN:
uuid:8f3ea2b9-f818-4024-8af9-bf59262710c4
Source identifiers:
215651
Local pid:
pubs:215651

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