No correlation between nigral degeneration and striatal plaques in Alzheimer's disease.
Although Alzheimer's disease may involve both the substantia nigra and the striatum, there is little information concerning the relationship between the resulting abnormalities in these reciprocally interconnected regions of the brain. We have examined the correlation between plaque density in the striatum and counts of neurons and neurofibrillary tangles in the pars compacta of the substantia nigra, in 12 cases of "pure" Alzheimer's disease (i.e. without clinical or neuropathological evidenc...Expand abstract
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