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Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair.

Abstract:

Many cancers display increased expression of histone deacetylases (HDACs) and therefore transcriptionally inactive chromatin, resulting in the downregulation of genes including tumour suppressor and DNA repair genes. Histone deacetylase inhibitors (HDACi) are a heterogeneous group of epigenetic therapeutics, showing promising anticancer effects in both pre-clinical and clinical settings, in particular the effect of radiosensitisation when administered in combination with radiotherapy. Radioth...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.2013.21

Authors


Groselj, B More by this author
Sharma, NL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
British journal of cancer
Volume:
108
Issue:
4
Pages:
748-754
Publication date:
2013-03-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:8f3503dd-1e1d-4b5b-8ad9-616dfb340858
Source identifiers:
375753
Local pid:
pubs:375753

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