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Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth.

Abstract:

Regions of hypoxia are a common feature of solid tumours. When tumour cells are exposed to hypoxic stress, transcription of a battery of genes is initiated. The angiogenic factor adrenomedullin (ADM) is a hypoxia regulated gene. ADM is thought to act through the G protein-coupled receptor calcitonin receptor-like receptor (CRLR), with specificity being conferred by the receptor associated modifying protein 2 (RAMP2). Here we report for the first time that ADM treated or stably transfected Ish...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1204422

Authors


Journal:
Oncogene
Volume:
20
Issue:
23
Pages:
2937-2945
Publication date:
2001-05-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:8f222c1f-c297-4b2a-be2c-d8586e98eec8
Source identifiers:
27312
Local pid:
pubs:27312

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