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Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.

Abstract:

1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12 adults with acute uncomplicated falciparum malaria and nine adults who attended in convalescence. 2 Intravenous halofantrine (1 mg kg(-1) infused in 1 h) was given every 8 h for a total of three doses in the acute study. Halofantrine cleared parasitaemia rapidly in all but one patient, with a mean (s.d.) parasite clearance time of 71 (29) h. Convalescent patients re...

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Publication status:
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Authors


Krishna, S More by this author
ter Kuile, F More by this author
Supanaranond, W More by this author
Pukrittayakamee, S More by this author
Teja-Isavadharm, P More by this author
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Journal:
British journal of clinical pharmacology
Volume:
36
Issue:
6
Pages:
585-591
Publication date:
1993-12-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:8f1d745f-e054-4c2d-8c6d-371af6835271
Source identifiers:
44368
Local pid:
pubs:44368

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