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Journal article

Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility.

Abstract:

Previously, we demonstrated that skeletal mass, structure and biomechanical properties vary considerably among 11 different inbred rat strains. Subsequently, we performed quantitative trait loci (QTL) analysis in four inbred rat strains (F344, LEW, COP and DA) for different bone phenotypes and identified several candidate genes influencing various bone traits. The standard approach to narrowing QTL intervals down to a few candidate genes typically employs the generation of congenic lines, whi...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2011.02.009

Authors


Journal:
Bone More from this journal
Volume:
48
Issue:
5
Pages:
1169-1177
Publication date:
2011-05-01
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
Language:
English
Keywords:
Pubs id:
pubs:124625
UUID:
uuid:8f1c922a-a737-456a-9400-a8fb7fbe7c6f
Local pid:
pubs:124625
Source identifiers:
124625
Deposit date:
2012-12-19

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