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Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.

Abstract:

Lmo2 is an oncogenic transcription factor that is frequently overexpressed in T-cell acute lymphoblastic leukemia (T-ALL), including early T-cell precursor ALL (ETP-ALL) cases with poor prognosis. Lmo2 must be recruited to DNA by binding to the hematopoietic basic helix-loop-helix factors Scl/Tal1 or Lyl1. However, it is unknown which of these factors can mediate the leukemic activity of Lmo2. To address this, we have generated Lmo2-transgenic mice lacking either Scl or Lyl1 in the thymus. We...

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Journal:
Blood More from this journal
Volume:
122
Issue:
12
Pages:
2093-2103
Publication date:
2013-09-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971

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