A stereoselective total synthesis of (±)-tormesol
- A general strategy for the synthesis of both trans/syn- and trans/anti-sphenolobane diterpenes has been developed, which utilizes an intramolecular ester enolate alkylation (IEEA) as a key step. A stereoselective total synthesis of (±)-tormesol (1), an unusual trans/syn-sphenolobane diterpene, was accomplished in 18 steps in 4.1% overall yield from readily available aldehyde 16. © 2011 Elsevier Ltd. All rights reserved.
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher copy:
- Copyright date:
- © 2011 Published by Elsevier Ltd. The full text of this article is not available in ORA. You may be able to access the article via the publisher copy link above.