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Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection

Abstract:

Background: Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations - despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded by the co-dominant alleles Hp1 and Hp2, have been variously associated with several infectious diseases, including malaria susceptibility. Methodology/Principal findings: Risk of a clinical malarial epis...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0000362

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Institution:
London School of Hygiene and Tropical Medicine
Department:
Medical Research Council (MRC) International Nutrition Group
Role:
Author
More by this author
Institution:
Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia
Role:
Author
More by this author
Institution:
Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia
Department:
Medical Research Council (MRC) International Nutrition Group
Role:
Author
More by this author
Institution:
Medical Research Council (MRC) Keneba, MRC Laboratories, The Gambia
Role:
Author
More by this author
Institution:
London School of Hygiene and Tropical Medicine
Department:
Medical Research Council (MRC) International Nutrition Group
Role:
Author
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Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
2
Issue:
4
Pages:
Article: e362
Publication date:
2007-04-05
DOI:
EISSN:
1932-6203
URN:
uuid:8f132597-bd1c-4769-a594-811400ca335d
Local pid:
ora:2499

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