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Journal article

Human platelet protein ubiquitylation and changes following GPVI activation

Abstract:

Platelet activators stimulate post-translational modification of signalling proteins to change their activity or their molecular interactions leading to signal propagation. One covalent modification is attachment of the small protein ubiquitin to lysine residues in target proteins. Modification by ubiquitin can either target proteins for degradation by the proteasome or act as a scaffold for other proteins. Pharmacological inhibition of deubiquitylases or the proteasome inhibition of platelet...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Files:
Publisher copy:
10.1055/s-0038-1676344

Authors


Unsworth, AJ More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Target Discovery Institute
McGouran, JF More by this author
Konietzny, R More by this author
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Publisher:
Thieme Publishing Group Publisher's website
Journal:
Thrombosis and Haemostasis Journal website
Volume:
119
Issue:
01
Pages:
104-116
Publication date:
2018-12-31
Acceptance date:
2018-10-10
DOI:
EISSN:
2567-689X
ISSN:
0340-6245
Pubs id:
pubs:935407
URN:
uri:8effa779-95e0-497a-bf84-7cda9d643d98
UUID:
uuid:8effa779-95e0-497a-bf84-7cda9d643d98
Local pid:
pubs:935407

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