- Abstract:
-
This study predicts the ultimate probability of survival of a newly arisen drug resistant mutant in a population of malaria parasites, with a view to understanding what conditions favour the evolution of drug resistance. Using branching process theory and a population genetics transmission model, the probabilities of survival of one- and two-locus new mutants are calculated as functions of the degree of drug pressure, the mean and variation in transmission rate, and the degree of natural sele...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1098/rspb.1997.0008
-
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- Journal:
- Proceedings. Biological sciences / The Royal Society
- Volume:
- 264
- Issue:
- 1378
- Pages:
- 53-59
- Publication date:
- 1997-01-05
- DOI:
- EISSN:
-
1471-2954
- ISSN:
-
0962-8452
- URN:
-
uuid:8ef85d1b-defd-4510-84bc-2e7ae7d26375
- Source identifiers:
-
90592
- Local pid:
- pubs:90592
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Survival probability of drug resistant mutants in malaria parasites.
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