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Journal article

Snapin promotes HIV‐1 transmission from dendritic cells by dampening TLR8 signaling

Abstract:

HIV-1 traffics through dendritic cells (DCs) en route to establishing a productive infection in T lymphocytes but fails to induce an innate immune response. Within DC endosomes, HIV-1 somehow evades detection by the pattern-recognition receptor (PRR) toll-like receptor 8 (TLR8). Using a phosphoproteomics approach we identified a robust and diverse signaling cascade triggered by HIV-1 upon entry into human DCs. A secondary siRNA screen of the identified signaling factors revealed several new m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embj.201695364

Authors


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Name:
Medical Research Council
Grant:
doctoral studentship
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Name:
Wellcome Trust
Grant:
clinical training fellowship
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Name:
National Institute for Health Research
Publisher:
EMBO Press
Journal:
EMBO Journal More from this journal
Volume:
36
Issue:
20
Pages:
2998-3011
Publication date:
2017-09-18
Acceptance date:
2017-08-22
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Keywords:
Pubs id:
pubs:724437
UUID:
uuid:8ef0378d-7d47-42e5-9c35-295d0c9178a9
Local pid:
pubs:724437
Source identifiers:
724437
Deposit date:
2017-08-29

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