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Renal biopsies from donors with acute kidney injury show different molecular patterns according to the post-transplant function

Abstract:

The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was to identify protein mediators implicated in either recovery or failure of these organs. Forty kidney biopsies from donors with (20) and without AKI (20) were selected and then subdivided according to the post-transplant outcome defined as a threshold of 45 ml/min for the eGFR at 1 year from transplantation. Tissue homogenates were anal...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-024-56277-x

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0003-3846-0101
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0002-0712-9937
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
14
Issue:
1
Article number:
6643
Place of publication:
England
Publication date:
2024-03-19
Acceptance date:
2024-03-04
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
38503767
Language:
English
Keywords:
Pubs id:
1889910
Local pid:
pubs:1889910
Deposit date:
2024-04-19

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