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A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.

Abstract:

Synthetic vectors based on reducible polycations consisting of histidine and polylysine residues (HIS RPCs) were evaluated for their ability to deliver nucleic acids. Initial experiments showed that RPC-based vectors with at least 70% histidine content mediated efficient levels of gene transfer without requirement for the endosomolytic agent chloroquine. Significant gene transfer was observed in a range of cell types achieving up to a 5-fold increase in the percentage of transfected cells com...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gni085

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Nucleic acids research
Volume:
33
Issue:
9
Pages:
e86
Publication date:
2005-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:8ee458fe-9717-45c2-9a4b-21bcc75c8edb
Source identifiers:
178346
Local pid:
pubs:178346

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