- Abstract:
-
Purpose
To determine whether the oxygen toxicity hypothesis can explain the distinctive spatio-temporal patterns of retinal degeneration associated with human retinitis pigmentosa (RP) and to predict the effects of antioxidant and trophic factor treatments under this hypothesis.
Methods
Three mathematical models were derived to describe the evolution of the retinal oxygen concentration and photoreceptor density over time. The first model considers only hyperoxia-i...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.6mb)
-
- Publisher copy:
- 10.1167/iovs.17-23177
-
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- Publisher:
- Association for Research in Vision and Ophthalmology Publisher's website
- Journal:
- Investigative Ophthalmology & Visual Science Journal website
- Volume:
- 59
- Pages:
- 1238-1249.
- Publication date:
- 2018-01-05
- Acceptance date:
- 2018-01-05
- DOI:
- EISSN:
-
1552-5783
- ISSN:
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0146-0404
- Pubs id:
-
pubs:817248
- URN:
-
uri:8edc3b99-b7db-4fbd-935a-f217b0fe7caa
- UUID:
-
uuid:8edc3b99-b7db-4fbd-935a-f217b0fe7caa
- Local pid:
- pubs:817248
- Copyright holder:
- Whiteley et al
- Copyright date:
- 2018
- Notes:
- Copyright 2018 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License.
Journal article
Predictive mathematical models for the spread and treatment of hyperoxia-induced photoreceptor degeneration in retinitis pigmentosa
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