Journal article icon

Journal article

Predictive mathematical models for the spread and treatment of hyperoxia-induced photoreceptor degeneration in retinitis pigmentosa

Abstract:

Purpose

To determine whether the oxygen toxicity hypothesis can explain the distinctive spatio-temporal patterns of retinal degeneration associated with human retinitis pigmentosa (RP) and to predict the effects of antioxidant and trophic factor treatments under this hypothesis.

Methods

Three mathematical models were derived to describe the evolution of the retinal oxygen concentration and photoreceptor density over time. The first model considers only hyperoxia-i...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1167/iovs.17-23177

Authors


Roberts, P More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Oxford college:
Linacre College
Luthert, P More by this author
Expand authors...
Publisher:
Association for Research in Vision and Ophthalmology Publisher's website
Journal:
Investigative Ophthalmology & Visual Science Journal website
Volume:
59
Pages:
1238-1249.
Publication date:
2018-01-05
Acceptance date:
2018-01-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
Pubs id:
pubs:817248
URN:
uri:8edc3b99-b7db-4fbd-935a-f217b0fe7caa
UUID:
uuid:8edc3b99-b7db-4fbd-935a-f217b0fe7caa
Local pid:
pubs:817248

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP