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Protection of mice against lethal challenge with herpes simplex virus by vaccination with an adenovirus vector expressing HSV glycoprotein B.

Abstract:

Increasing attention has been focused on the use of recombinant mammalian viruses as potential vaccines. Recombinant human adenoviruses are one of the more promising vaccine vectors because they can be easily constructed and because live adenovirus vaccines have been administered orally to large numbers of military recruits without adverse reactions. In order to examine the efficacy of human adenoviruses as vaccines we have studied the immunity induced by a recombinant adenovirus vector, AdgB...

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Publication status:
Published

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Authors


McDermott, MR More by this author
Graham, FL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Johnson, DC More by this author
Journal:
Virology
Volume:
169
Issue:
1
Pages:
244-247
Publication date:
1989-03-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:8ed32b86-3c41-4548-8d0e-fadc51f69f91
Source identifiers:
102203
Local pid:
pubs:102203

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