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An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection

Abstract:

The airway epithelium secretes proteins that function in innate defense against infection. Bactericidal/permeability-increasing fold-containing family member A1 (BPIFA1) is secreted into airways and has a protective role during bacterial infections, but it is not known whether it also has an antiviral role. To determine a role in host defense against influenza A virus (IAV) infection and to find the underlying defense mechanism, we developed transgenic mouse models that are deficient in BPIFA...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/mi.2017.45

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Department:
Oxford,MSD,Jenner Institute
Role:
Author
Publisher:
Springer Nature
Journal:
Mucosal Immunology More from this journal
Volume:
11
Pages:
71–81
Publication date:
2017-05-17
Acceptance date:
2017-04-17
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
Pmid:
28513596
Language:
English
Pubs id:
pubs:801152
UUID:
uuid:8ecc12ce-fbdb-4bec-80ba-f78713c61939
Local pid:
pubs:801152
Source identifiers:
801152
Deposit date:
2017-12-19

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