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Journal article

Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells.

Abstract:

Inflammation triggers an increase in osteoclast (bone resorbing cell) number and activity. Osteoclastogenesis is largely controlled by a triad of proteins consisting of a receptor (RANK), a ligand (RANK-L) and a decoy receptor (osteoprotegerin, OPG). Whilst RANK is expressed by osteoclasts, RANK-L and OPG are expressed by osteoblasts. The long chain polyunsaturated fatty acid (LCPUFA) arachidonic acid (AA, 20:4n-6) and its metabolite prostaglandin E2 (PGE2), are pro-inflammatory and PGE2 is a...

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Publication status:
Published

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Authors


Poulsen, RC More by this author
Wolber, FM More by this author
Moughan, PJ More by this author
Kruger, MC More by this author
Journal:
Prostaglandins and other lipid mediators
Volume:
85
Issue:
1-2
Pages:
42-48
Publication date:
2008-02-05
DOI:
ISSN:
1098-8823
URN:
uuid:8ec607e9-55f4-4309-b1e1-c9d580a846ef
Source identifiers:
230756
Local pid:
pubs:230756

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