- Abstract:
-
Inflammation triggers an increase in osteoclast (bone resorbing cell) number and activity. Osteoclastogenesis is largely controlled by a triad of proteins consisting of a receptor (RANK), a ligand (RANK-L) and a decoy receptor (osteoprotegerin, OPG). Whilst RANK is expressed by osteoclasts, RANK-L and OPG are expressed by osteoblasts. The long chain polyunsaturated fatty acid (LCPUFA) arachidonic acid (AA, 20:4n-6) and its metabolite prostaglandin E2 (PGE2), are pro-inflammatory and PGE2 is a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.prostaglandins.2007.10.004
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- Journal:
- Prostaglandins and other lipid mediators
- Volume:
- 85
- Issue:
- 1-2
- Pages:
- 42-48
- Publication date:
- 2008-02-05
- DOI:
- ISSN:
-
1098-8823
- URN:
-
uuid:8ec607e9-55f4-4309-b1e1-c9d580a846ef
- Source identifiers:
-
230756
- Local pid:
- pubs:230756
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Long chain polyunsaturated fatty acids alter membrane-bound RANK-L expression and osteoprotegerin secretion by MC3T3-E1 osteoblast-like cells.
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