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C1q and its growing family.

Abstract:

C1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innate immunity, C1q can engage a broad range of self and non-self ligands via its heterotrimeric globular (gC1q) domain and thus trigger the classical pathway. The trimeric gC1q signature domain has been identified in a variety of non-complement proteins that can be grouped together as a C1q family. The X-ray c...

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Publication status:
Published

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Publisher copy:
10.1016/j.imbio.2006.11.001

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Roumenina, LT More by this author
Gadjeva, M More by this author
Kojouharova, MS More by this author
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Journal:
Immunobiology
Volume:
212
Issue:
4-5
Pages:
253-266
Publication date:
2007
DOI:
EISSN:
1878-3279
ISSN:
0171-2985
URN:
uuid:8ebeb3b2-4fff-43e1-8116-9c697416c2a6
Source identifiers:
243065
Local pid:
pubs:243065

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