Journal article
FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.
- Abstract:
-
Single-nucleotide polymorphisms in the first intron of the ubiquitously expressed FTO gene are associated with obesity. Although the physiological functions of FTO remain unclear, food intake is often altered when Fto expression levels are manipulated. Furthermore, deletion of FTO from neurones alone has a similar effect on food intake to deletion of FTO in all tissues. These results indicate that FTO expression in the brain is particularly important. Considerable focus has been placed on the...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Medical Research Council
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 6
- Issue:
- 11
- Article number:
- e27968
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:8ea713f1-0a54-4717-b910-5c933a200737
- Local pid:
- pubs:216136
- Source identifiers:
-
216136
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- McTaggart et al
- Copyright date:
- 2011
- Notes:
- Copyright 2011 McTaggart et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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