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Harnessing regulatory t cells for clinical use in transplantation: The end of the beginning

Abstract:

Owing to the adverse effects of immunosuppression and an inability to prevent chronic rejection, there is a pressing need for alternative strategies to control alloimmunity. In three decades, regulatory T cells (Tregs) have evolved from a hypothetical mediator of adoptively transferred tolerance to a well-defined population that can be expanded ex vivo and returned safely to patients in clinical trials. Herein, we review the historical developments that have permitted these advances and the c...

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Publisher copy:
10.1111/ajt.12647

Authors


Whatcott, AG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Publisher:
Blackwell Publishing Ltd
Journal:
American Journal of Transplantation
Volume:
14
Issue:
4
Pages:
750-763
Publication date:
2014
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:8ea4c9dc-ce93-4edd-9a13-ac5d56f95650
Source identifiers:
459359
Local pid:
pubs:459359

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