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New Routes and Opportunities for Modular Construction of Particulate Vaccines: Stick, Click, and Glue

Abstract:

Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-chimeric VLP-based vaccines are highly successful licensed products (e.g., hepatitis B surface antigen VLPs as a hepatitis B virus vaccine). Chimeric VLPs are designed to take advantage of the VLP framework by decorating the VLP with a different antigen. Despite decades of effort, there have been few licensed chimeric VLP vaccines. Classic approaches to create chimeric VLPs are either genetic fusion or ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2018.01432

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0001-8870-7147
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Article number:
1432
Publication date:
2018-06-26
Acceptance date:
2018-06-11
DOI:
EISSN:
1664-3224
Pmid:
29997617
Language:
English
Keywords:
Pubs id:
pubs:864773
UUID:
uuid:8ea155d3-ea6c-4757-b8e9-4df9ace2f3b6
Local pid:
pubs:864773
Deposit date:
2019-03-15

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