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Journal article

Growth hormone, insulin-like growth factor-I and the cortisol-cortisone shuttle.

Abstract:

In peripheral tissues, corticosteroid hormone action is determined, in part, through the activity of 11beta-hydroxysteroid dehydrogenases (11beta-HSD), two isozymes of which interconvert hormonally active cortisol (F) and inactive cortisone (E). 11beta-HSD type 2 (11beta-HSD2) inactivates F to E in the kidney, whilst 11beta-HSD type 1 (11beta-HSD1) principally performs the reverse reaction activating F from E in the liver and adipose tissue. Alteration in expression of these 11beta-HSD isozym...

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Publication status:
Published

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Publisher copy:
10.1159/000048126

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Role:
Author
Journal:
Hormone research
Volume:
56 Suppl 1
Issue:
SUPPL. 1
Pages:
1-6
Publication date:
2001-01-01
DOI:
EISSN:
1423-0046
ISSN:
0301-0163
URN:
uuid:8e9fccee-fc71-4d29-98e7-89ad8892e01f
Source identifiers:
482111
Local pid:
pubs:482111

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