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Memory B-cell responses against merozoite antigens after acute Plasmodium falciparum malaria, assessed over one year using a novel multiplexed fluorospot assay

Abstract:

Memory B cells (MBCs) are believed to be important for the maintenance of immunity to malaria, and these cells need to be explored in the context of different parasite antigens and their breadth and kinetics after natural infections. However, frequencies of antigen-specific MBCs are low in peripheral blood, limiting the number of antigens that can be studied, especially when small blood volumes are available. Here, we developed a multiplexed reversed B-cell FluoroSpot assay capable of simulta...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
11
Article number:
619398
Publication date:
2021-02-12
Acceptance date:
2020-12-21
DOI:
EISSN:
1664-3224
Language:
English
Keywords:
Pubs id:
1167923
Local pid:
pubs:1167923
Deposit date:
2021-03-25

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