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Tyrosine residues at the immunoglobulin-C-type lectin inter-domain boundary of intimin are not involved in Tir-binding but implicated in colonisation of the host

Abstract:

Intimin is an outer membrane adhesion molecule involved in bacterial adhesion to intestinal epithelium by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli and Citrobacter rodentium. Intimin binds to the translocated intimin receptor, Tir, which is delivered to the plasma membrane of the host cell by a type III protein translocation system. Intimin is also implicated in binding to a host cell-encoded intimin receptor (Hir). The rece...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
Elsevier
Journal:
Microbes and Infection More from this journal
Volume:
4
Issue:
14
Pages:
1389-1399
Publication date:
2002-11-01
Acceptance date:
2002-09-10
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
Pmid:
12475629
Language:
English
Keywords:
Pubs id:
pubs:98251
UUID:
uuid:8e95dc81-9ed0-4424-97d0-5d88a9b8cbbe
Local pid:
pubs:98251
Source identifiers:
98251
Deposit date:
2017-05-31

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