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Journal article

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.

Abstract:

ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a human genetic disease associated with defects in such proteins. To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked) syndrome, we conditionally inactivated the homolog in mice, Atrx, at the 8- to 16-cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.0020058

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS genetics More from this journal
Volume:
2
Issue:
4
Article number:
e58
Publication date:
2006-04-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
UUID:
uuid:8e95c26a-7b82-4460-8688-ea60815d798f
Local pid:
pubs:124888
Source identifiers:
124888
Deposit date:
2012-12-19

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