Journal article
The Inflammatory Bowel Disease Drug Azathioprine Induces Autophagy via mTORC1 and the Unfolded Protein Response Sensor PERK
- Abstract:
-
BACKGROUND:Genetic studies have strongly linked autophagy to Crohn's disease (CD), and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD) drugs on autophagy and investigate molecular mechanisms of action and functional outcomes in relation to this cellular process. METHODS:Autophagy marker LC3 was evaluated by confocal fluorescence microscopy and flow cytometry. Drug mechanism of ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Publisher copy:
- 10.1093/ibd/izz039
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Inflammatory Bowel Diseases Journal website
- Volume:
- 25
- Issue:
- 9
- Pages:
- 1481–1496
- Publication date:
- 2019-03-19
- Acceptance date:
- 2019-02-22
- DOI:
- EISSN:
-
1536-4844
- ISSN:
-
1078-0998
- Pmid:
-
30889246
- Source identifiers:
-
984012
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:984012
- UUID:
-
uuid:8e95bf68-9a60-4d32-acd8-08a10870d234
- Local pid:
- pubs:984012
- Deposit date:
- 2019-04-26
Terms of use
- Copyright date:
- 2019
If you are the owner of this record, you can report an update to it here: Report update to this record