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The Inflammatory Bowel Disease Drug Azathioprine Induces Autophagy via mTORC1 and the Unfolded Protein Response Sensor PERK

Abstract:

BACKGROUND:Genetic studies have strongly linked autophagy to Crohn's disease (CD), and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD) drugs on autophagy and investigate molecular mechanisms of action and functional outcomes in relation to this cellular process. METHODS:Autophagy marker LC3 was evaluated by confocal fluorescence microscopy and flow cytometry. Drug mechanism of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ibd/izz039

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-6357-9684
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Publisher:
Oxford University Press Publisher's website
Journal:
Inflammatory Bowel Diseases Journal website
Volume:
25
Issue:
9
Pages:
1481–1496
Publication date:
2019-03-19
Acceptance date:
2019-02-22
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
Pmid:
30889246
Source identifiers:
984012
Language:
English
Keywords:
Pubs id:
pubs:984012
UUID:
uuid:8e95bf68-9a60-4d32-acd8-08a10870d234
Local pid:
pubs:984012
Deposit date:
2019-04-26

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