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Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase pin1

Abstract:

Ring-shaped cohesin keeps sister chromatids paired until cleavage of its Scc1/Rad21 subunit by separase triggers chromosome segregation in anaphase. Vertebrate separase is held inactive by mutually exclusive binding to securin or Cdk1-cyclin B1 and becomes unleashed only upon ubiquitin-dependent degradation of these regulators. Although most separase is usually found in association with securin, this anaphase inhibitor is dispensable for murine life while Cdk1-cyclin B1-dependent control of s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Funding agency for:
Novak, B
Publisher:
Elsevier Publisher's website
Journal:
Molecular cell Journal website
Volume:
58
Issue:
3
Pages:
495-506
Publication date:
2015-05-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:8e910e66-4a7e-4ee0-af94-196e66954abd
Source identifiers:
519775
Local pid:
pubs:519775
Language:
English

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