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An expanded family of proteins with BPI/LBP/PLUNC-like domains in trypanosome parasites: an association with pathogenicity?

Abstract:

Trypanosomatids are protozoan parasites that cause human and animal disease. Trypanosoma brucei telomeric ESs (expression sites) contain genes that are critical for parasite survival in the bloodstream, including the VSG (variant surface glycoprotein) genes, used for antigenic variation, and the SRA (serum-resistance-associated) gene, which confers resistance to lysis by human serum. In addition, ESs contain ESAGs (expression-site-associated genes), whose functions, with few exceptions, have ...

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Publication status:
Published

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Publisher copy:
10.1042/bst0390966

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Biochemical Society transactions More from this journal
Volume:
39
Issue:
4
Pages:
966-970
Publication date:
2011-08-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Language:
English
Keywords:
Pubs id:
pubs:167536
UUID:
uuid:8e8dea72-1976-4107-952e-16e6e37c1eb2
Local pid:
pubs:167536
Source identifiers:
167536
Deposit date:
2012-12-19

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