Journal article
Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing
- Abstract:
-
Any replicating system in which heritable variants with differing replicative potentials can arise is subject to a Darwinian evolutionary process. The continually replicating adult tissue stem cells that control the integrity of many tissues of long-lived, multicellular, complex vertebrate organisms, including humans, constitute such a replicating system. Our suggestion is that somatic selection for mutations (or stable epigenetic changes) that cause an increased rate of adult tissue stem cel...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Journal of Theoretical Biology Journal website
- Volume:
- 489
- Article number:
- 110153
- Publication date:
- 2020-01-11
- Acceptance date:
- 2020-01-04
- DOI:
- EISSN:
-
1095-8541
- ISSN:
-
0022-5193
- Pmid:
-
31935413
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1085274
- Local pid:
- pubs:1085274
- Deposit date:
- 2021-01-22
Terms of use
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Ltd. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.jtbi.2020.110153
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