- Abstract:
-
Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulner...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.00790-12
-
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- Journal:
- Journal of virology
- Volume:
- 86
- Issue:
- 20
- Pages:
- 11373-11379
- Publication date:
- 2012-10-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:8e893d9d-11f6-469a-8fcb-b058737f8c9b
- Source identifiers:
-
345602
- Local pid:
- pubs:345602
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.
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