Journal article icon

Journal article

Delaying bacillus Calmette-Guerin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age.

Abstract:

Bacillus Camette-Guérin (BCG) vaccine is the only licensed vaccine against tuberculosis, yet its protective efficacy is highly variable between different geographical regions. We hypothesized that exposure to nontuberculous mycobacteria attenuates BCG immunogenicity by inducing mycobacterial-specific regulatory T cells (Tregs). Gambian neonates were recruited at birth and randomized to receive BCG vaccination either at birth or at 4 1/2 mo. Mycobacterial immune responses were assessed at birt...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4049/jimmunol.1000552

Authors


Adetifa, UJ More by this author
Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
185
Issue:
4
Pages:
2620-2628
Publication date:
2010-08-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:8e88d39b-1d7c-4ff7-8aad-42bfbe9fd758
Source identifiers:
65904
Local pid:
pubs:65904

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP