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Delaying bacillus Calmette-Guerin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age.

Abstract:

Bacillus Camette-Guérin (BCG) vaccine is the only licensed vaccine against tuberculosis, yet its protective efficacy is highly variable between different geographical regions. We hypothesized that exposure to nontuberculous mycobacteria attenuates BCG immunogenicity by inducing mycobacterial-specific regulatory T cells (Tregs). Gambian neonates were recruited at birth and randomized to receive BCG vaccination either at birth or at 4 1/2 mo. Mycobacterial immune responses were assessed at birt...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1000552

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Journal:
Journal of Immunology More from this journal
Volume:
185
Issue:
4
Pages:
2620-2628
Publication date:
2010-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:65904
UUID:
uuid:8e88d39b-1d7c-4ff7-8aad-42bfbe9fd758
Local pid:
pubs:65904
Source identifiers:
65904
Deposit date:
2012-12-19

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