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Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.

Abstract:

In order to extend the chemical diversity available for organic polyketide synthesis, the concept of propionate scanning was developed. We observed that naturally occurring polyketides frequently comprise not only acetate, but also some propionate as building blocks. Therefore our approach consists of a systematic replacement of some of the acetate building blocks during synthesis by propionate moieties, resulting in additional methyl groups that may give rise to different properties of the p...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmc.2008.11.076

Authors


Zimmermann, TJ More by this author
Niesen, FH More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Oppermann, U More by this author
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Journal:
Bioorganic and medicinal chemistry
Volume:
17
Issue:
2
Pages:
530-536
Publication date:
2009-01-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:8e8837e3-961a-4efa-acb5-44e666f2d35d
Source identifiers:
41076
Local pid:
pubs:41076

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