An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.

Journal article

Clinically, inflammatory pain is far more persistent than that typically modelled pre-clinically, with the majority of animal models focussing on short-term effects of the inflammatory pain response. The large attrition rate of compounds in the clinic which show pre-clinical efficacy suggests the need for novel models of, or approaches to, chronic inflammatory pain if novel mechanisms are to make it to the market. A model in which a more chronic inflammatory hypersensitivity phenotype is prof...

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Authors: Wilson, A; Medhurst, S; Dixon, C; Bontoft, N; Winyard, L

• Publication status: Published
• Journal: European journal of pain (London, England)
• Volume: 10
• Issue: 6
• Pages: 537-549
• Publication date: 2006-08-01
• DOI: 10.1016/j.ejpain.2005.08.003
• EISSN: 1532-2149
• ISSN: 1090-3801
• Language: English
• Keywords: Pain; Sulfones; Phenols; Receptors, N-Methyl-D-Aspartate; Chronic Disease; Male; Piperidines; Stifle; Weight-Bearing; Arthritis; Sulfides; Rats; Nitric Oxide Synthase Type II; Time Factors; Animals; Disease Models, Animal; Cyclooxygenase 2 Inhibitors; Lactones; Freund's Adjuvant