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An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.

Abstract:

Clinically, inflammatory pain is far more persistent than that typically modelled pre-clinically, with the majority of animal models focussing on short-term effects of the inflammatory pain response. The large attrition rate of compounds in the clinic which show pre-clinical efficacy suggests the need for novel models of, or approaches to, chronic inflammatory pain if novel mechanisms are to make it to the market. A model in which a more chronic inflammatory hypersensitivity phenotype is prof...

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Publication status:
Published

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Journal:
European journal of pain (London, England) More from this journal
Volume:
10
Issue:
6
Pages:
537-549
Publication date:
2006-08-01
DOI:
EISSN:
1532-2149
ISSN:
1090-3801
Language:
English
Keywords:
Pubs id:
pubs:33252
UUID:
uuid:8e86c969-ee88-4b3e-827c-b8ef8f43ed97
Local pid:
pubs:33252
Source identifiers:
33252
Deposit date:
2012-12-19

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