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Journal article

Plasma membrane rafts engaged in T cell signalling: new developments in an old concept.

Abstract:

Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results le...

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Publication status:
Published

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Publisher copy:
10.1186/1478-811x-7-21

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cell communication and signaling : CCS More from this journal
Volume:
7
Issue:
1
Pages:
21
Publication date:
2009-01-01
DOI:
EISSN:
1478-811X
ISSN:
1478-811X
Language:
English
Pubs id:
pubs:27572
UUID:
uuid:8e7f4607-0901-4cb4-9a50-79a4bcefd07f
Local pid:
pubs:27572
Source identifiers:
27572
Deposit date:
2012-12-19

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