Journal article
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
- Abstract:
-
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs in cellular studies. Our collection provides inhibitors and antagonists that together modulate most of the key regulatory methylation marks on histones H3 and H4, providing an important resource for modulating cellular epigenomes. We describe a co...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Article number:
- 19
- Publication date:
- 2019-01-03
- Acceptance date:
- 2018-12-04
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
30604761
Item Description
- Language:
- English
- Pubs id:
-
pubs:956386
- UUID:
-
uuid:8e7b4984-39e0-4a39-97ab-997e705de088
- Local pid:
- pubs:956386
- Source identifiers:
-
956386
- Deposit date:
- 2019-01-23
Terms of use
- Copyright holder:
- Scheer et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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