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Antibiotic collateral sensitivity is contingent on the repeatability of evolution

Abstract:

Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential drug regimens derived from in vitro evolution experiments may have overstated therapeutic benefit, predicting a collaterally sensitive response where cross-resistance ultimately occurs. We quan...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-08098-6

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Computer Science
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Article number:
334
Publication date:
2019-01-18
Acceptance date:
2018-12-13
DOI:
ISSN:
2041-1723
Source identifiers:
958798
Pubs id:
pubs:958798
UUID:
uuid:8e7827d5-f63c-40a3-ad28-e0b998dacd10
Local pid:
pubs:958798
Deposit date:
2019-01-10

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