Journal article
Antibiotic collateral sensitivity is contingent on the repeatability of evolution
- Abstract:
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Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential drug regimens derived from in vitro evolution experiments may have overstated therapeutic benefit, predicting a collaterally sensitive response where cross-resistance ultimately occurs. We quan...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1038/s41467-018-08098-6
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Article number:
- 334
- Publication date:
- 2019-01-18
- Acceptance date:
- 2018-12-13
- DOI:
- ISSN:
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2041-1723
- Source identifiers:
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958798
Item Description
- Pubs id:
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pubs:958798
- UUID:
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uuid:8e7827d5-f63c-40a3-ad28-e0b998dacd10
- Local pid:
- pubs:958798
- Deposit date:
- 2019-01-10
Terms of use
- Copyright holder:
- Nichol et al
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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