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Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.

Abstract:

The chromatin-associated protein ATRX was originally identified because mutations in the ATRX gene cause a severe form of syndromal X-linked mental retardation associated with alpha-thalassemia. Half of all of the disease-associated missense mutations cluster in a cysteine-rich region in the N terminus of ATRX. This region was named the ATRX-DNMT3-DNMT3L (ADD) domain, based on sequence homology with a family of DNA methyltransferases. Here, we report the solution structure of the ADD domain o...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0704057104

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
104
Issue:
29
Pages:
11939-11944
Publication date:
2007-07-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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