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Compensating for over-production inhibition of the Hsmar1 transposon in Escherichia coli using a series of constitutive promoters

Abstract:

Background: Transposable elements (TEs) are a diverse group of self-mobilizing DNA elements. Transposition has been exploited as a powerful tool for molecular biology and genomics. However, transposition is sometimes limited because of auto-regulatory mechanisms that presumably allow them to cohabit within their hosts without causing excessive genomic damage. The papillation assay provides a powerful visual screen for hyperactive transposases. Transposition is revealed by the activation of a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13100-020-0200-5

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Division:
MSD
Sub department:
Pathology Dunn School
Role:
Author
Publisher:
BioMed Central
Journal:
Mobile DNA More from this journal
Volume:
11
Issue:
1
Publication date:
2020-01-10
Acceptance date:
2020-01-01
DOI:
EISSN:
1759-8753
Language:
English
Pubs id:
1084287
Local pid:
pubs:1084287
Deposit date:
2020-02-06

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