Functions of nonclassical MHC and non-MHC-encoded class I molecules.

Journal article

Fascinating recent discoveries have focused attention on the nonclassical class I molecules. They can exert their function at most levels of the immune response, being part of both innate and adaptive immune systems. They not only have specialized antigen-presentation functions but also play important immunoregulatory roles: HLA-E regulates natural killer cells by interacting with CD94/NKG2 receptors; the MIC (MHC class I chain related) glycoproteins appear crucial to the activation of gammad...

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Authors: Braud, V; Allan, D; Mcmichael, A

• Publication status: Published
• Journal: Current opinion in immunology
• Volume: 11
• Issue: 1
• Pages: 100-108
• Publication date: 1999-02-01
• DOI: 10.1016/s0952-7915(99)80018-1
• EISSN: 1879-0372
• ISSN: 0952-7915
• Language: English
• Keywords: Animals; Membrane Proteins; Humans; Antigens, CD1; Immunity; Histocompatibility Antigens Class I; HLA Antigens