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Journal article

Clinical development of gene therapy for colorectal cancer.

Abstract:
Colorectal cancer (CRC) is the second most common type of malignancy in Western nations. Improvements in surgical and radiotherapeutic techniques and the increased availability of new cytotoxic drugs have improved outcome, but 50% of patients still die from recurrent or metastatic disease. Several features of its natural history render CRC a good candidate for gene therapy. Techniques include gene replacement, virus-directed enzyme-prodrug therapy, immune manipulation and virotherapy, all of which have entered clinical trials.
Publication status:
Published

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Publisher copy:
10.1038/nrc1147

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
Journal:
Nature reviews. Cancer More from this journal
Volume:
3
Issue:
8
Pages:
615-622
Publication date:
2003-08-01
DOI:
EISSN:
1474-1768
ISSN:
1474-175X
Language:
English
Keywords:
Pubs id:
pubs:246213
UUID:
uuid:8e6b40cb-e3b0-4e1e-8f5d-3ae33be1d9da
Local pid:
pubs:246213
Source identifiers:
246213
Deposit date:
2012-12-19

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