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Journal article

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.

Abstract:

Hypoxia-inducible factor (HIF) plays an important role in determining patterns of gene expression in cancer. HIF is down-regulated in oxygenated cells by a series of Fe (II) and 2-oxoglutarate dependent dioxygenases that hydroxylate specific residues in the regulatory HIF-alpha subunits. Because these enzymes require ascorbate for activity in vitro we analyzed the effects of ascorbate on HIF in human cancer cell lines. Ascorbate at physiological concentrations (25 micro M) strikingly suppress...

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Publication status:
Published

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Authors


Knowles, HJ More by this author
Harris, AL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
Cancer research
Volume:
63
Issue:
8
Pages:
1764-1768
Publication date:
2003-04-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:8e68525f-21b4-4361-a1bd-db6065d8b673
Source identifiers:
9332
Local pid:
pubs:9332

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