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Journal article

The effect of diazepam on indices of 5-HT function in man.

Abstract:

The effects of acute and chronic diazepam administration on L-tryptophan induced prolactin release was studied in seven male volunteers. Acute diazepam diminished the prolactin neuroendocrine response to L-tryptophan. On chronic administration this effect was lost, suggesting tolerance had developed. The sedative effects of L-tryptophan were unaltered by either acute or chronic diazepam administration. A possible explanation for the tolerance development to the neuroendocrine effects may be t...

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Publication status:
Published

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Authors


Franklin, M More by this author
Murdock, P More by this author
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Journal:
Pharmacology, biochemistry, and behavior
Volume:
24
Issue:
5
Pages:
1491-1495
Publication date:
1986-05-05
DOI:
EISSN:
1873-5177
ISSN:
0091-3057
URN:
uuid:8e67ba94-0cc9-4c31-814b-994cf3c4e259
Source identifiers:
185934
Local pid:
pubs:185934

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