Journal article icon

Journal article

Primaquine induced haemolysis in G6PD heterozygous females treated for the radical cure of Plasmodium vivax malaria: a nested cohort study

Abstract:

Background
Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD heterozygous females are mosaics who, because of X-chromosome inactivation (Lyonisation), may have low G6PD activity in the majority of their erythrocytes, yet they usually are reported as G6PD “normal” by current phenotypic screening tests. Their haemolytic risk when treated with ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.1002224

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
089179/Z/09/Z
Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Publication date:
2017-02-07
Acceptance date:
2016-12-16
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:666788
UUID:
uuid:8e60b411-d750-4261-8565-9141628e78e6
Local pid:
pubs:666788
Source identifiers:
666788
Deposit date:
2016-12-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP